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NorthShore Plastic Surgery
847.504.2300

Mark Sisco, MD

Division of Plastic and Reconstructive Surgery
NorthShore University HealthSystem
501 Skokie Boulevard
Northbrook, IL 60062
847.504.2300
847.504.2305 fax

 

EDUCATION

2000
Doctor of Medicine, Northwestern University Feinberg School of Medicine
1996
Bachelor of Arts, Columbia College, Columbia University
Concentration in Art History

GRADUATE MEDICAL EDUCATION

2008-2009
Clinical Fellow in Reconstructive Microsurgery, Division of Plastic Surgery
Memorial Sloan-Kettering Cancer Center
Program Director: Dr. Peter Cordeiro
2007-2008
Administrative Chief Resident, Division of Plastic and Reconstructive Surgery
McGaw Medical Center of Northwestern University
Program Director: Dr. Gregory A. Dumanian
2005-2007
Resident, Division of Plastic and Reconstructive Surgery
McGaw Medical Center of Northwestern University
Program Director: Dr. Gregory A. Dumanian
2001-2004
Intern and Resident, Department of Surgery
McGaw Medical Center of Northwestern University
Program Director: Dr. Richard H. Bell

POSTDOCTORAL RESEARCH TRAINING

2004-2005
Research Fellow, Wound Healing Research Laboratory
Division of Plastic and Reconstructive Surgery
Northwestern University Feinberg School of Medicine
Cutaneous ischemia-reperfusion injury and hypertrophic scarring
PI: Dr. Thomas A. Mustoe
2000-2001
Research Fellow, Wound Healing Research Laboratory
Division of Plastic and Reconstructive Surgery
Northwestern University Feinberg School of Medicine
Wound-healing response to aging and ischemia
PI: Dr. Thomas A. Mustoe

BOARD CERTIFICATION

2010
American Board of Plastic Surgery

MEDICAL LICENSURE

State of Illinois
036-111485
State of New York
#247380-1 (expired)
NPI #1245498658

ACADEMIC APPOINTMENTS

2015- Present
Clinical Associate Professor, Department of Surgery
University of Chicago, Pritzker School of Medicine, Chicago, IL.

2010- 2015
Clinical Assistant Professor, Department of Surgery
University of Chicago, Pritzker School of Medicine, Chicago, IL.
2008-2009
Clinical Instructor, Department of Surgery
Memorial Sloan-Kettering Cancer Center, New York, NY.
2007-2008
Clinical Instructor, Department of Surgery
Northwestern University Feinberg School of Medicine, Chicago, IL.

CLINICAL APPOINTMENTS

2015-Present
Chief, Division of Plastic Surgery, Department of Surgery
NorthShore University HealthSystem, Evanston, IL.

2009-Present
Attending Physician, Division of Plastic Surgery, Department of Surgery
NorthShore University HealthSystem, Evanston, IL.

COMMITTEE SERVICE

2015-Present
Surgical Executive Committee
NorthShore University HealthSystem
2014-Present
OR Committee
NorthShore University HealthSystem
2013-Present
Surgical Quality Committee
NorthShore University HealthSystem
2012-Present
Breast Quality Improvement Subcommittee
NorthShore University HealthSystem
2012-Present
Specialty Care Practice Network Committee
NorthShore University HealthSystem
2011-Present
Breast Program Leadership Committee
Kellogg Cancer Center
NorthShore University HealthSystem
2011-Present
Physician Engagement & Communications Committee
NorthShore University HealthSystem Medical Group
2011-2013
Coding and Payment Policy Committee
American Society of Plastic Surgeons
2011-2013
In-Service Examination Committee
American Society of Plastic Surgeons
1996-2000
Executive Curriculum Committee
Northwestern University Feinberg School of Medicine

HONORS AND AWARDS

2011
Scientific Exhibit of Exceptional Merit, American College of Surgeons Clinical Congress
2008
Edelstone-Bendix Chief Resident Research Prize, Northwestern University
2000
Alpha Omega Alpha Honor Society
1996
Columbia College, cum laude in Art History

PROFESSIONAL SOCIETY MEMBERSHIPS

Fellow, American College of Surgeons
Active Member, American Society of Plastic Surgeons
Active Member, American Society for Reconstructive Microsurgery

PROFESSIONAL and SCIENTIFIC SERVICE

2015-Present

Editorial Board Member, Journal of Surgical Oncology
2010-Present
Peer Reviewer, Journal of Surgical Research
2011
Peer Reviewer, Journal of Investigative Dermatology
2005
Peer Reviewer, Wound Repair and Regeneration

PATENTS

2015
Mustoe TA, Dean NM, Sisco M, Kryger Z, Bennett FC. “Method for Reducing Scarring During Wound Healing Using Antisense Compounds Directed to CTGF.” U.S. Patent 8,946,172, issued February 3, 2015.
2010
Dean NM, Mustoe TA, Sisco M, Kryger Z, Bennett FC. “Method for Reducing Scarring During Wound Healing Using Antisense Compounds Directed to CTGF” (WO/2010/027831)

RESEARCH GRANTS/CONTRACTS

2014
NorthShore University HealthSystem Breast and Ovarian Research Program Concept/Pilot Award
“Does Contralateral Prophylactic Mastectomy Improve Satisfaction and Pychosocial Health?”
Co-Primary Investigator, $31,239
2000-2001
 Buehler Center on Aging, Northwestern University
“A Gene Array Assay of Wound Healing in an Aged Ischemic Model.”
Co-Investigator, $13,000
2000-2001
American Society for Aesthetic Plastic Surgery
“Microarray Gene Expression Analysis of Human Scarring.”
Co-Investigator, $8,000
1997
Northwestern University Medical School Summer Research Fellowship
“Arterial Base Deficit as a Predictor of Resuscitation in Septic Patients.”
Student Investigator, $2,500

SCHOLARLY WORK

ORIGINAL, PEER-REVIEWED RESEARCH ARTICLES

  1. Mogford JE, Sisco M, Bonomo SR, Robinson AM, and Mustoe TA: “Impact of Aging on Gene Expression in a Rat Model of Ischemic Cutaneous Wound Healing.” J Surg Res. 2004;118(2):190-6. (co-first author)
  2. Sisco M, Liu WR, Kryger ZB, and Mustoe TA: “Reduced Up-Regulation of Cytoprotective Genes in Rat Cutaneous Tissue During the Second Cycle of Ischemia-Reperfusion.” Wound Repair Regen. 2007;15(2):203-12.
  3. Kryger ZB, Sisco M, Roy N, Lu L, Rosenberg D, and Mustoe TA: “The Temporal Expression of the TGF-beta Pathway in the Rabbit Ear Model of Wound Healing and Scarring.” J Am Coll Surg. 2007;205(1):78-88.
  4. Sisco M, Chao JD, Kim I, Mogford JE, Mayadas TN, and Mustoe TA: “Delayed Wound Healing in Mac-1–Deficient Mice Is Associated with Normal Monocyte Recruitment.” Wound Repair Regen. 2007;15(4):566-71.
  5. Brown RJ, Lee MJ, Sisco M, Kim JY, Roy N, and Mustoe TA: “High-Dose Ultraviolet Light Exposure Reduces Scar Hypertrophy in a Rabbit Ear Model.” Plast Recon Surg. 2008;121(4):1165-72.
  6. Sisco M, Kryger ZB, O’Shaughnessy KD, Kim PS, Schultz GS, Ding XZ, Roy NK, Dean NM, and Mustoe TA: “Antisense Inhibition of Connective Tissue Growth Factor (CTGF/CCN2) mRNA Limits Hypertrophic Scarring Without Affecting Wound Healing in Vivo.” Wound Repair Regen. 2008;16(5):661-73.
  7. Sisco M, Du H, Warner JP, Howard MA, Winchester DP, Yao K: “Have We Expanded the Equitable Delivery of Post-Mastectomy Breast Reconstruction in the New Millennium? Evidence From the National Cancer Data Base.” J Am Coll Surg. 2012;215(5):658-66.
  8. Rundell V, Beck R, Wang E, Gutowski K, Sisco M, Fenner G, Howard M: “Complication Outcomes of Tutoplast-Derived Human Acellular Dermal Matrix (NeoForm and Allomax) in Prosthetic Breast Reconstruction.” J Plast Reconstr Aesthet Surg. 2014 Oct;67(10):1345-51.
  9. Yao K, Liederbach E, Tang R, Lei L, Czechra T, Sisco M, Howard M, Hulick P, Weissman S, Winchester DJ, Coopey SB, Smith BL: “Nipple Sparing Mastectomy In Brca1/2 Mutation Carriers: An Interim Analysis And Review Of The Literature.” Ann Surg Oncol. 2015 Feb;22(2):370-6.
  10. Butz D, Lapin B, Wang C, Yao K, Johnson D, Song D, Sisco M: “Age Is a Predictor of 30-Day Complications After Autologous but Not Implant-Based Post-Mastectomy Breast Reconstruction” Plast Recon Surg. 2015 Feb;135(2):253e-61e.
  11. Liederbach E, Sisco M, Wang C, Pesce C, MD, Sharpe S, Winchester DJ, Yao K: “Wait Times for Breast Surgical Operations, 2003-2011: A Report from the National Cancer Data Base.” Ann Surg Oncol. 2015 Mar;22(3):899-907.
  12. Sisco M, Johnson DB, Wang C, Rasinski K, Rundell VL, and Yao K: “The Quality-of-Life Benefits of Breast Reconstruction Do Not Diminish with Age.” J Surg Oncol. 2015 May;111(6):663-8.
  13. Johnson DB, Lapin, B, Wang C, Yao K, Rasinski K, Rundell VL, and Sisco M: “Age Does Not Affect Perceptions of Recovery or Long Term Chest and Upper Body Morbidity After Post-Mastectomy Breast Reconstruction.” Ann Plast Surg. In press.
  14. Butz D, Shenaq DS, Keppler B, Rundell VL, Murphy G, Thiel J, Sisco M, Pesce C, Howard M: “Use of Liposomal Bupivacaine (Exparel™) Is Associated with Reduced Pain and Length of Stay after Mastectomy with Implant-Based Reconstruction.” Plast Recon Surg Global Open. In press.
  15. Silva A, Lapin A, Yao K, Song D, Sisco M: “The Effect of Contralateral Prophylactic Mastectomy on Perioperative Complications. A NSQIP Analysis.” Ann Surg Oncol. In press.

REVIEWS, CHAPTERS, BOOKS

  1. Sisco M and Mustoe TA: “Animal Models of Ischemic Wound Healing. Toward an Approximation of Human Chronic Cutaneous Ulcers in the Rabbit and Rat.” Methods Mol Med. 2003;78:55-65.
  2. Kryger ZB and Sisco M, Eds.: Practical Plastic Surgery. Austin: Landes Bioscience, 2007.
  3. Sisco M and Bauer BS: “Craniofacial Syndromes and Sequences.” In Bentz ML, Bauer BS, and Zucker R, Eds.: Principles and Practice of Pediatric Plastic Surgery. St. Louis: Quality Medical Publishing, 2007.
  4. Sisco M and Disa JJ: “Mandible Reconstruction.” In Marsh J and Perlyn C, Eds.: Decision Making in Plastic Surgery. St. Louis: Quality Medical Publishing, In Press.

CASE REPORTS, TECHNICAL NOTES, DISCUSSIONS, LETTERS

  1. Sisco M and Dumanian GA: “A Simple Technique to Anchor Prosthetic Mesh to Bone.” Plast Recon Surg. 2005;116(7):2059-60.
  2. Sisco M and Dumanian GA: Invited Discussion of “Salvaging Limbs in Cases of Severe Purpura Fulminans: Advantages of Free Flaps.” Plast Recon Surg. 2006;118(3):686-7.
  3. Erickson BA, Dumanian GA, Sisco M, Jang TL, Halverson AL, and Gonzalez CM: “Rectourethral Fistula Associated with Two Short Segment Urethral Strictures in the Anterior and Posterior Urethra: Single-Stage Reconstruction Using Buccal Mucosa and a Radial Forearm Fasciocutaneous Free Flap.” Urology. 2006;67(1):195-8.
  4. Sisco M and Dumanian GA: “Anterior Interosseous Nerve Syndrome Following Shoulder Arthroscopy. A Report of Three Cases.” J Bone Joint Surg Am. 2007;89(2):392-5.
  5. Sisco M and Dumanian GA: “The Implantable Venous Doppler for Perforator Flap Monitoring: Report of a False-Negative Signal.” Plast Recon Surg. 2008;121(4):223e-4e.
  6. Sisco M and Disa JJ: Invited Discussion of “NPWT I: The Paradox of Negative Pressure Wound Therapy.” Plast Recon Surg. 2009; 123(2):599-600.
  7. MacIver RH, Sundaresan S, DeHoyos AL, Sisco M, and Blum MG: “Mucosal Tube Technique for Creation of Esophageal Anastomosis after Esophagectomy.” Ann Thorac Surg. 2009;87(6):1703-7.
  8. Sisco M and Warner JP: “Refinements in Anchoring the Gracilis Muscle for Facial Reanimation.” Plast Recon Surg. 2013:131(5)857e-858e.

PRESENTATIONS

  1. Zhao Y, Sisco M, Mogford J, and Mustoe TA: “Effects of Ischemia on a Model of Non-Contractile Cutaneous Wound Healing in the Rat.” Oral Presentation. Wound Healing Society Annual Meeting, Toronto, June 2000.
  2. Sisco M, Mogford JE, Robinson AM, Zhao Y, and Mustoe TA: “Gene Array Analysis of the Impact of Aging and Ischemia on Wound Healing in Rats.” Oral Presentation. Wound Healing Society Annual Meeting, Albuquerque, NM, June 2001.
  3. Sisco M, Chao J, Kim I, Mayadas-Norton T, Mogford JE, and Mustoe TA:  “Delayed Wound Healing in Mac-1 (CD11b/CD18) Integrin Knockout Mice.” Oral Presentation. Wound Healing Society Annual Meeting, Albuquerque, NM, June 2001.
  4. Cross KJ, Sisco M, Mogford J, and Mustoe TA. “A Novel Ischemic Wound Healing Model in the Rat: a Bipedicled Back Flap with Internal Controls.” Oral Presentation. Wound Healing Society Annual Meeting, June 2002.
  5. Kryger ZB, Sisco M, Roy NK, and Mustoe TA: “The Temporal mRNA Expression of the TGF-Beta Pathway in the Rabbit Ear Model of Hypertrophic Scarring.” Poster Presentation. Plastic Surgery Research Council, Toronto, May 2005.Wound Rep Regen 13(2), A4-27.
  6. Kryger ZB, Sisco M, Lu WR, and Mustoe TA: “Attenuated Stress- and Hypoxia-Driven Gene Expression in a Rat Model of Repetitive Cutaneous Ischemia-Reperfusion Injury” Oral Presentation. American College of Surgeons Clinical Congress, San Francisco, October 2005. J Am Coll Surg 201(3), S58-9.
  7. Sisco M, Kryger ZB, Jia SX, Schultz GS, Dean NM, and Mustoe TA: “Antisense Oligonucleotides Against Transforming Growth Factor-Beta Delay Wound Healing in a Rabbit Ear Model.” Oral Presentation. American College of Surgeons Clinical Congress, San Francisco, October 2005. J Am Coll Surg 201(3), S60.
  8. Sisco M, Kryger ZB, Schultz GS, Roy NK, Dean N, and Mustoe TA: “Antisense Inhibition of Connective Tissue Growth Factor Limits Hypertrophic Scarring In Vivo: Evidence for a Specific Target to Reduce Fibrosis.” Oral Presentation. Plastic Surgery Research Council, Dana Point, CA, May 2006.
  9. Sisco M and Dumanian GA: “The Oblique Rectus Abdominis Myocutaeous Flap for Vaginal Reconstruction.” Oral Presentation. Midwestern Association of Plastic Surgeons, Chicago, May 2007.
  10. Sisco M, Du H, Howard MA, Warner JP, Gutowski KA, Song DH, Winchester DJ, Winchester DP, and Yao K: “Have We Expanded the Equitable Delivery of Postmastectomy Breast Reconstruction in the New Millenium? Evidence from the National Cancer Data Base.” Scientific Exhibit of Exceptional Merit. American College of Surgeons Clinical Congress, San Francisco, October 2011.
  11. Spiguel L, Yao K, Du H, Martz B, Turk M, Howard M, Sisco M, Warner J, Winchester DP, Sener S, and Winchester DJ: “Nipple Sparing Mastectomy: An Option for Cancer Treatment and Risk Reduction.” Oral Presentation. Society of Surgical Oncology Cancer Symposium, San Antonio, March 2011.
  12. Sisco M: “Alloplastic Breast Reconstruction following Nipple-Sparing Mastectomy.” Oral Presentation. Chicago Breast Reconstruction Symposium, Chicago, September 2012.
  13. Sisco M, Johnson DB, Wang CE, and Yao KA: “Do older women benefit from post-mastectomy breast reconstruction?” Poster Presentation. San Antonio Breast Cancer Symposium, December 2013. Cancer Research 73 (24 Supp.), P2-19-02.
  14. Liederbach E, Pesce C, Sisco M, Winchester DJ, Yao K: “Wait Times for Breast Cancer Surgery, 2003-2010: A Report from the National Cancer Database.” Society of Surgical Oncology Cancer Symposium, Phoenix, March 2014. Ann Surg Oncol 21, S64.
  15. Nocon C, Liederbach E, Sisco M, Yao K, Gerber ME, Lewis CM, Bhayani MK: “Factors Affecting Delays to Surgery for Oral Tongue Carcinoma in the National Cancer Data Base.” Oral Presentation. AAO-HNSF Annual Meeting, Orlando, September 2014. Otolaryngol Head Neck Surg 151:1 S56.
  16. Johnson D, Lapin B, Wang C, Yao K, Sisco M: “Does age predict perceptions of recovery and long-term chest and upper body morbidity after postmastectomy breast reconstruction?” Poster Presentation. ASCO Breast Cancer Symposium, San Francisco, September 2014.
  17. Silva S, Lapin B, Yao K, Song D, Sisco M: “A NSQIP analysis of 30-day complications after bilateral versus unilateral mastectomy with immediate reconstruction.” Oral Presentation. ASCO Breast Cancer Symposium, San Francisco, September 2014.
  18. Butz D, Shenaq DS, Rundell VL, Kepler B, Liderbach E, Thiel J, Pesce C, Murphy G, Sisco M, Howard MA: “Pain Control Using Liposomal Bupivacaine vs Bupivacaine Pain Pump and a Control Group in Implant Based Breast Reconstruction Patients.” Oral Presentation. American Association of Plastic Surgeons, Scottsdale, April 2015.

INSTRUCTIONAL COURSES

  1. Chicago Rhinoplasty Symposium. NorthShore University HealthSystem. Evanston, IL. May 2010.
  2. Incorporating Nipple Sparing Mastectomy (NSM) Into Your Practice. American Society of Plastic Surgeons Annual Meeting. Toronto. October 2010.
  3. Chicago Rhinoplasty Symposium. NorthShore University HealthSystem. Evanston, IL. May 2011.
  4. Comprehensive Approach to Nipple Sparing Mastectomy. American Society of Plastic Surgeons Annual Meeting. Denver. September 2011.
  5. Chicago Rhinoplasty Symposium. NorthShore University HealthSystem. Evanston, IL. January 2012.
  6. Comprehensive Approach to Nipple Sparing Mastectomy. American Society of Plastic Surgeons Annual Meeting. San Diego. September 2013.

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